Human Lymphoblastoid Cell Genetic Analysis of gene expression.docVIP

 PAGE \* MERGEFORMAT 15 Human Lymphoblastoid Cell Genetic Analysis of gene expression Authors: Li Dong Guo Hua Lin Liu Zheng Ying Zhang Jinwang Abstract 14 from the CEPH family pedigrees selected four families of 50 individuals lymphoblastoid cell gene expression data and SNP genotype analysis of the data showed that the same family of differentially expressed genes in a small, and different families of differentially expressed genes in more. Compatriots in the same family with non-sibling pairs of the variance ratio range of about 0.001 to 0.967, from 20 SNPs were screened out of 5 of a genotype was significantly higher than other genotypes of the SNP. Keywords: Gene expression; genetic; family; SNP In the issue of individual differences, the researchers faced with the problem of genetic and environmental differences in the formation of the individual role in the process. Many researchers have put forward different theories to explain individual differences caused by genetic and environmental genes. The 20th century, the early 90s, the University of Pennsylvania McClearn [1] drawing on statistical genetics related to genetic variation and environmental variation factors on the biological traits of model theory to describe the genetic and environmental influence on individual differences in the difference model to reveal individual differences in genetic and environment on the formation of the impact. In fact, many gene expression level showed a natural variation of species, from yeast to humans. The human genome has led to the genetic variation among individuals, but also makes the feasibility of gene expression analysis has been. Microarray experiments simultaneously measure thousands of genes can be generated after the mRNA levels of transcription, mRNA showed that the level of the corresponding gene expression levels. Identification of differentially expressed genes in biologically significant, but it is also the cla