Hydroxypropyl-β-cyclodextrin on Astragaloside packages used in research co-operation.docVIP

 PAGE \* MERGEFORMAT 17 Hydroxypropyl-β-cyclodextrin on Astragaloside packages used in research co-operation 【Abstract】 Objective To prepare Astragaloside - hydroxypropyl-β-cyclodextrin inclusion compound and to study their co-operation with the package and the solubilization effect. Methods aqueous solution - prepared by mixing Astragaloside - hydroxypropyl-β-cyclodextrin inclusion complexes, using optical rotation determination of incremental inclusion ratio; and take advantage of high-performance liquid chromatography determination of solubility and dissolution of Astragaloside degrees, in order to investigate its solubilization. Results hydroxypropyl-β-cyclodextrin can be formed with astragaloside molar ratio of 1:1 inclusion, inclusion, after the solubility of astragaloside from the original 22.2 μg * ml-1 increased to 286.8 μg * ml - 1, dissolution from 26.4% to 71.2%. Conclusion Astragaloside - hydroxypropyl-β-cyclodextrin inclusion complexes can significantly increase drug solubility and dissolution. Keywords: Astragaloside hydroxypropyl-β-cyclodextrin dissolution rate than the solubility Inclusion of Astragaloside IV with Hydroxypropyl-β-cyclodextrin Abstract: ObjectiveTo prepare Astragaloside IV-hydroxypropyl-β-cyclodextrin Inclusion complex, as well as to study the inclusion mechanism and the effect as the solubilizer.MethodsAstragaloside IV-HP-β-CD was prepared by solution-agitation technology, and the inclusion ratio was studied by measuring optical activity. At the same time, the solubility and dissolution were measured by HPLC.ResultsThe inclusion ratio of Astragaloside IV-hydroxypropyl-β-cyclodextrin was 1:1. The solubility of Astragaloside IV increased from 22.2 μg * ml - 1 to 286.8 μg * ml-1, and the dissolution increased from 26.4% to 71.2%. ConclusionThe solubility and dissolution of Astragaloside IV can be improved by preparing the inclusion complex with hydroxypropyl-β-cyclodextrin. Keywords:: Astraga