Hydroxypropyl.docVIP

 PAGE \* MERGEFORMAT 10 Hydroxypropyl 【Key Words】 hydroxypropyl Abstract: hydroxypropyl-β-cyclodextrin features, application and preparation of inclusion complexes were reviewed. Hydroxypropyl-β-cyclodextrin safe dose of big, and blood compatibility is good, does not change the efficacy, increase the water-soluble drugs, stability, is considered more promising drug carrier materials. Keywords: hydroxypropyl-β-cyclodextrin; characteristics; application; Preparation Hydroxypropyl-β-cyclodextrin (hydroxypropylbetacyclodextr in; HPβCD) is a hydroxyalkyl-β-cyclodextrin derivative. It is not only with β-cyclodextrin, as for many compounds have an excellent role in the envelope can be improved by the stability of the envelope material, and the water-soluble high, can increase the release of drugs has been the speed envelope and bioavailability. In this paper, the characteristics of hydroxypropyl-β-cyclodextrin, application and inclusion of the preparation methods are reviewed for its application in medical research, provide a reference. The characteristics of a hydroxypropyl-β-cyclodextrin [1] In the “Chinese Pharmacopoeia” “Essential Drugs List” in insoluble, water-insoluble drugs account for about 1 / 3, increase the water solubility of these drugs to improve the efficacy of great significance. The use of β-cyclodextrin or its derivatives and drugs to increase the co-ordination role of the water-soluble drugs is the method of extensive research over the years. However, the low solubility of β-cyclodextrin itself, limits its application; and hydroxypropyl-β-cyclodextrin water-soluble good thermal stability, high and low hemolysis, is low toxicity, safe and effective drug solubilizer, is considered is very promising excipients for injection [2]. It has the following features. 1.1 hydroxypropyl-β-cyclodextrin at room temperature, water-soluble high, generally more than 50% (at room temperature, the solubility of 750 mg