Hydroxycamptothecin semi-solid lipid nanoparticles Technology.docVIP

 PAGE \* MERGEFORMAT 9 Hydroxycamptothecin semi-solid lipid nanoparticles Technology [Abstract] Objective To prepare the semi-hydroxy-camptothecin solid lipid nanoparticles (HCPT-SSLN). Method in single-factor study, based on the Orthogonal Design by prescription and preparation process, and prepared under optimum conditions HCPT-SSLN nano-solution for quality evaluation. Results prepared HCPT-SSLN average particle size of 130.5 nm, polydispersity index of 0.18, the drug loading of 2.51%, the encapsulation efficiency was 79.19%, ξ potential of-33.1mV; nano-solution at 4 ℃ for 6 months, nanoparticles appearance, size and encapsulation rate was not changed significantly. Conclusion The prepared HCPT-SSLN encapsulation rate and higher drug loading, particle size distribution uniformity, stability is good, the clinical application of HCPT provide a broader perspective. [Keywords:] hydroxy camptothecin; semi-solid lipid nanoparticles; Preparation Process Abstract: ObjectiveTo prepare hydroxycamptothecin semisolid lipid nanoparticles (HCPT-SSLN). MethodsBased on the single-factor experiment, the HCPT-SSLN was prepared by orthogonal design for optimization of formulation and technology. Then the obtained SSLN was evaluated. ResultsThe mean particle size of the prepared HCPT-SSLN was 130.5nm, Polydispersity index (PI) was 0.18, drug loading (DL) was 2.51%, entrapment efficiency (EE) was 79.19%, ξ potential was-33.1mV; Placed at 4 ℃ for 6 months, the appearance, particle size and entrapment efficiency of SSLN were all stable.ConclusionThe HCPT-SSLN has high entrapment efficiency and drug loading, uniform particle size, good stability, which provides an extensive prospect for clinical application of HCPT. Keywords:: Hydroxycamptothecin; Semisolid lipid nanoparticles (SSLN); Preparation Nanoparticles containing drug delivery systems since 1976, first reported by the Birrenbach since, owing to its biodegradable, low immunity, there is definitely targeting the ad