Human papilloma virus infection and cervical cancer continue to change-related risk factors.docVIP

 PAGE \* MERGEFORMAT 29 Human papilloma virus infection and cervical cancer continue to change-related risk factors Abstract Cervical cancer is the most common female genital tract malignancies, high-risk type human papilloma virus (HPV) persistent infection and cervical intraepithelial lesions and cervical cancer are closely linked. The study found a continuing high-risk HPV infection is not only with the HPV genetic variation and traits related to changes in the host’s own immune response, genetic factors, also has a decisive influence on their changes. The risk factors for persistent infection with HPV research is in the ascendant, is expected to cervical cancer diagnosis, prognosis markers to achieve a breakthrough. Full-text of the relevant progress in this area in recent years to do a review. Keywords: Cervical cancer gene mutation of human papillomavirus integration of genetic susceptibility to immune escape Cervical cancer is a common gynecological cancer, a serious threat to women’s lives and health. A large number of epidemiological studies confirmed that human papilloma virus (human papillomavirus, HPV) infection is an important development of cervical carcinoma environmental factors. However, in the women infected with HPV, most can be self-limiting, only a few women develop persistent infection, and progressed to cervical intraepithelial neoplasia (cervical intraepithelial neoplasia, CIN), and even cervical cancer, indicating that cervical cancer, occurred during, there are also a number of other risk factors play a role. In recent years, studies have shown that, in addition to external factors such as environment and lifestyle, the host and the virus itself may be related to the variation of the factors of the occurrence and development of the disease have a certain relevance. In-depth understanding of HPV and host factors in the pathogenesis of cervical cancer the role of their mutual relations, the existence of early to i