Human papillomavirus (HPV) vaccine study.docVIP

 PAGE \* MERGEFORMAT 25 Human papillomavirus (HPV) vaccine study [Keywords:] cervical cancer Health Net News: Li Juan Wang Youchun Cervical cancer is seriously endangering women’s health and lives of disease, each year about 50 million new cases, 25 million deaths Death, is caused by the second leading cause of death among women, most of them in developing countries, accounting for about 80% [1] . In 1977, a German scholar ZurHausen other specimens from the cervical cancer found in the human papilloma virus (humanp apillomavirus, HPV) DNA, speculated that HPV infection and cervical cancer related to the occurrence. Further molecular epidemiological Evidence shows that, HPV and the human variety of cancers, especially cervical cancer have a close relationship. By the International Cancer Research institutes (IARC) organizations in 22 countries conducted for the cause of invasive cervical cancer (ICC) of the HPV types The survey [2]. Histological diagnosis of ICC in 1000 found that 99.7% of cases with positive HPVDNA, its On the type of HPV is mainly HPV16 (53%) and HPV18 (15%). A body’s immune response to HPV infection HPV is a nipple polyoma virus family vacuoles (Papovaviridae) papilloma virus genus, is a kind of skin infection And the mucosal squamous epithelium of the small DNA viruses. Its genome double-stranded circular DNA, length 7.5 ~ 8.0kb, containing 8 open Open reading frame (openreadingframes, ORFs), according to different functions divided into 3 districts: (1) early region (e arlyregion, E area): respectively, encoding E1, E2, E4, E5, E6, E7, etc. 6 early protein involved in disease Toxic DNA replication, transcription, translation regulation and transformation functions. (2) late region (lateregion, L area) : Encoding the major coat protein L1 and minor coat protein L2. (3) non-coding region (uncodingregion, UC R) or the upstream regulatory region (URR): containing HPV genomic DNA replication starting point and the