Human preimplantation embryo of progress in the mechanism of anti-ROS.docVIP

 PAGE \* MERGEFORMAT 30 Human preimplantation embryo of progress in the mechanism of anti-ROS Of: Zou Baolin, in of state, Li Qiang, Hu Shumin, Zhou Yu Yan [Abstract] ROS can change the molecular structure of many cells, but also can cause the human preimplantation embryo development arrest and necrosis. Human embryos there are many protection mechanisms against ROS, and these protective mechanisms synergy exists between. present in follicular and oviductal fluid in the outer protective mechanism mainly composed of non-enzymatic antioxidants, including GSH, hypotaurine, taurine, VC, etc.; exist in embryonic cells mainly by the protection mechanism within the SOD, GPX and glutamine synthesis enzymes cysteamine, and the transcription of these enzymes codon exists in human oocytes, embryos and oviduct. In this paper, the human preimplantation embryo made of a light anti-ROS mechanisms of synthesis and exploration to . [Keywords:] people; preimplantation embryos; ROS; mechanism [Abstract] ROS can alter most types of cellular molecules, and also induce development block and retardation for human embryos.Multiple mechanisms of embryo protection against ROS exist, and these have complementary actions.External protection, present in follicular and tubal fluids, mainly comprises non enzymatic antioxidants, such as hypotaurine, taurine and ascorbic acid; Internal protection present in embryo or oocytes, mainly comprises antioxidant enzymes: superoxide dismutase, glutathione peroxidase and glutamylcysteine #8203;#8203;synthetase.Transcripts encoding for these enzymes are present in the human oocyte, embryo and oviduct . In this paper, the defense mechanisms against ROS in human pre implantation embryos are simply reviewed and researched. [Keywords:] human; pre implantation embryo; ROS; mechanism Currently, through the human assisted reproductive technology (IVF or ICSI) of human embryos produced in vitro environment, there are many protection mechanisms,