HTLV-1 infected persons ocular clinical manifestations of.docVIP

 PAGE \* MERGEFORMAT 27 HTLV-1 infected persons ocular clinical manifestations of Author: Jiang Feng, CAI Ping, Jin-chang, LIU Xiu-ming Abstract Human T cell leukemia virus type Ⅰ (HTLV-1) infection is relatively rare, mainly popular in Japan, the Caribbean, Central and South America. Known to infect primarily by ocular manifestations, including adult T-cell leukemia (ATL) in patients with malignant infiltration of the eye, retinal degeneration, eye neuropathy, HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM / TSP) in patients with keratoconjunctivitis sicca, and HTLV-1 uveitis (HU) and so on. HTLV-1 related eye diseases are growing in scope, duration of abnormal immune regulation may occur in the eye caused by disease or eye cancer, genetic and environmental factors may be different populations of patients with HTLV-1 play a role in ocular manifestations . In this paper, HTLV-1-related ocular manifestations and the latest developments are reviewed. Keywords: human T cell leukemia virus type Ⅰ 0 Introduction Human T-cell leukemia virus type Ⅰ (HTLV-1) was first discovered in 1980 belongs to reverse tumor virus RNA virus family subfamily mammalian C-type virus, was the first one was found with human disease-related retrovirus. HTLV-1 mainly via sexual contact, blood transfusion, mother to child vertical transmission and breast-feeding, etc. [1]. Diagnosis is primarily dependent on serological detection methods are commonly used enzyme-linked immunosorbent assay, particle agglutination, immunofluorescence, Western blot and radioimmunoassay precipitation detection. HTLV-1 occurs mainly in Japan, the Caribbean, Central and South America. It is reported that the positive rate of serum in southwestern Japan was as high as 37%, far more than other areas, such as the Caribbean (2% ~ 6%), Brazil (0.08% ~ 1.8%) and the United States (0.02%) and other non-endemic areas [2 -4]. With the human immunodeficiency v