Huang AD SSTF rats on the ultrastructure of hippocampal neurons and anti-oxidation.docVIP

 PAGE \* MERGEFORMAT 15 Huang AD SSTF rats on the ultrastructure of hippocampal neurons and anti-oxidation Study: New Dongya Jie Zhang Wang Ruiting [Abstract] Objective Huang SSTF (SSTF) on learning and memory in rat model of AD function, ultrastructure of hippocampal neurons and anti-oxidation effects. Methods Morris water maze learning and memory abilities of rats, electron microscopy Observation of the ultrastructure of hippocampal neurons; serum superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH Px) content. Results of model rats 2 min the number passing through a plateau region were markedly reduced (P lt;0.01), time spent in the platform quadrant significantly reduced (P lt;0.01), dose group the number of times through the platform area was significantly increased compared with the model group (P lt;0.05 ), time spent in the platform quadrant was significantly longer than the model group (P lt;0.05). ultrastructure of hippocampal neurons in control group the normal, serious injury model group, treatment group compared with model group to reduce injury. model group, the SOD, CAT, GSH Px levels were markedly lower (P lt;0.05), treatment group was significantly higher than model group (P lt;0.05). Conclusion SSTF A25-35 injection on hippocampal learning and memory in rats and reduce the ultrastructure of hippocampal neurons injury in rats. The mechanism may be enhanced antioxidant enzyme activity in rats, thus reducing the active oxygen on neuronal damage. [Keywords:] amyloid protein; Huang SSTF; superoxide dismutase; catalase; glutathione peroxide [Abstract] Objective To investigate the protection of scutellaria baicalensis stem leaf total flavonoid (SSTF) on memory deficits, neuron ultrastructure damage induced by bilateral injection A25-35 on rat hippocampus and its antioxidative mechanism. Methods 30 male Wistar rats were randomly divided into three groups, 10 rats for each group. The distilled water or SSTF (50 mg kg-1