Human papillomavirus and esophageal squamous cell carcinoma of the relationship between.docVIP

 PAGE \* MERGEFORMAT 25 Human papillomavirus and esophageal squamous cell carcinoma of the relationship between Keywords: Human papillomavirus; esophageal squamous cell carcinoma; malignant Esophageal squamous cell carcinoma is the most common human malignancy, one of the top ten, new cases worldwide each year is about 310.4 thousand, the incidence rate in the world vary greatly in different geographic regions [1]. China is a high incidence of esophageal squamous cell carcinoma, the incidence rate in the world. 1982 Syrjanen [2] the first 60 cases of esophageal squamous cell carcinoma through organized morphology observed that about 40% with the characteristic changes of HPV infection, followed by the reports of the relationship between HPV and esophageal cancer many, many scholars confirmed that HPV infection in the incidence of esophageal squamous cell carcinoma there is a certain correlation, but there are some scholars hold the opposite view. HPV infection rates reported in the literature in different countries, different regions or in the same area very different from [3  5]. The reasons for these differences may be related to HPV detection methods used by researchers of different races on HPV, as well as the genetic susceptibility to esophageal squamous cell carcinoma of the diversity of other related causes. HPV is now on the relationship between infection and esophageal squamous cell carcinoma of the relevant studies are summarized below: 1 HPV biological characteristics of HPV is a principal parasitic on the squamous epithelium of the small molecule DNA virus, is a papilloma virus, Branch, shape into Icosahedron, outside the shell surrounding, non-lipid, no capsule, a diameter of about 50 ~ 60nm. The closed-loop HPV genome is double-stranded DNA, whose length is 7200 ~ 8000bp, molecular weight of about 5.2 × 10KDa. HPV genome structure according to the functions can be divided into three coding regions: early region (E regi