Human papilloma virus (HPV) detection and its clinical application.docVIP

 PAGE \* MERGEFORMAT 18 Human papilloma virus (HPV) detection and its clinical application Keywords: clinical application of human papilloma virus, HPV Human papilloma virus (HPV) infection in the general popular around the world, via the viral DNA sequence alignment, can be identified more than 200 of more than HPV subtypes. HPV virus can cause infection in humans and animals primarily infected with host epithelial cells and tissues lining. According to type of infected tissue can be divided into two kinds of skin type and mucosal-type: epidermal-type is mainly caused by hands, feet and skin infections; mucosa-type is caused by the mouth, throat, respiratory and genito-urinary tract infection. HPV can cause hand, foot skin warts generation (such as: flat wart, verruca vulgaris, plantar warts ... and so on), mainly caused by proliferation of skin keratinocytes, usually 1 to 5 years after the lesion would be a natural ease, but some are also infected with the face can cause skin cancer, some can cause oral squamous cell carcinoma. HPV infection is one of the main cause of cervical cancer and its means of infection are generally caused by sexual intercourse, but through the mother’s womb caused by HPV infection is one of the ways. Clinically, HPV subtypes according to the size of pathogenicity or carcinogenic risk of different sizes can be divided into low-risk HPV type, high-risk two broad categories. In Table 1 HPV subtypes and associated clinical disease in Table 2, low-risk type, high-risk HPV subtypes and associated clinical disease A carcinogenic HPV is a ring of double-stranded DNA virus, the genome size of approximately 7900bp, according to gene function can be divided into three main genetic parts: ① the upstream regulatory region, a regulation, transcription functions; ② early areas, this part contains the E1 , E2, E4, E5, E6, E7 and other genes whose protein with the replication and production of carcinogenic; ③ late District, this p