Hyperacute cerebral ischemia and perfusion imaging Diffusion MRI Study.docVIP

 PAGE \* MERGEFORMAT 13 Hyperacute cerebral ischemia and perfusion imaging Diffusion MRI Study [Abstract] Objective use of magnetic resonance diffusion and perfusion imaging study before embolization, and thrombolysis after the different regions of brain tissue hemodynamic changes, and determine the value of the penumbra. Methods 60 male SD rats (280 ~ 320g, were randomly divided into 3 groups A, B, C group, A group for the control group (n = 10, B group, 2 h ischemia group (n = 5 × 5, C group 6 hours of ischemia group (n = 5 × 5. with modified Zea Longa suture method in the rat model of reversible middle cerebral artery occlusion, at reperfusion before and after reperfusion 2h, 24h, respectively, with the Signa Profile 3.0T MRI brain coronal line diffusion imaging, perfusion weighted (perfusion weighted imaging, PWI evaluation of blood reperfusion. Results A group (sham operation group NEI DWI and cerebral blood flow perfusion parametric maps were normal. B group (ischemia reperfusion 2h reperfusion group appeared before a large shallow DWI high signal light, filling a large area of #8203;#8203;perfusion shown to reduce the area, DWI PWI abnormal area was significantly smaller than the abnormal area, 2h after reperfusion and 24h DWI abnormal area of #8203;#8203;slightly reduced compared with before infusion (Pgt; 0.05, perfusion images of blood flow gradually recovered, rNEI value gradually increased, DWI and PWI abnormalities abnormal area is an area of #8203;#8203;convergence. C group (ischemia reperfusion group, reperfusion 6h before the DWI high signal appears large, the scope is consistent with the PWI after reperfusion with re- prolonged perfusion no significant change in area of #8203;#8203;DWI, perfusion images, uneven restoration of blood flow, local perfusion defect exists. Conclusion diffusion and perfusion magnetic resonance imaging of cerebral blood flow can provide quantitative cerebral blood flow dynamics change information, and provides the