Immunosuppressive agents curcumin reversed insulin resistance in.docVIP

 PAGE \* MERGEFORMAT 11 Immunosuppressive agents curcumin reversed insulin resistance in 【Abstract】 【Objective】 To investigate curcumin (curcumin) for the treatment of insulin resistance and its mechanism. 【Methods】 The use of insulin resistance in mice to observe the effects of curcumin on the level of insulin resistance in mice, transcription factor I-?-Owned B? Zhuo, changes in circulating cytokines. 【Results】 ① curcumin can inhibit TNF? Zhuo stimulated Fao cells, NF-?-Owned B activation; ② curcumin treated mice, no significant drop in fasting blood glucose levels, but fasting insulin levels decreased by about 30%, glucose tolerance curve levels are significantly decreased; ③ cycle TNF? Zhuo [(34.5 ± 3.4) pg / mL vs (31.3 ± 1.1) pg / mL] levels did not change significantly, while the IL-1? Zhuo [(33.9 ± 3.2) pg / mL vs (15.6 ± 1.1) pg / mL] and IL-6 [(72.1 ± 9.8) pg / mL vs (47.2 ± 5.3) pg / mL] were significantly suppressed; ④ insulin-stimulated IRS-1 tyrosine phosphate acid levels were significantly increased while the level of phosphorylation of insulin receptor did not change significantly. And IRS-1 tyrosine phosphorylation levels of parallel, P85 phosphorylation levels increased significantly, AKT phosphorylation of the levels increased significantly. 【Conclusion】 curcumin can improve insulin sensitivity in mice, there is treatment to improve the obesity-induced insulin resistance role. Keywords: curcumin; NF-?-Owned B; insulin; resistance) Abstract: 【Objective】 To investigate inhibitory effect of curcumin and its mechanism on insulin resistance. 【Methods】 Curcumin co-operated high fat diets were tested for the effect of curcumin on obesity induced insulin resistance in rodent model. Transcription factor I and circulating cytokines were also detected after curcumin treatment. 【Results】 (1) Curcumin inhibited TNF? Zhuo-stimulated NF-?-owned B activation in Fao cells. (2) The fasting plasma glucose level was not obviously decrease