In patients with chronic obstructive pulmonary disease induced sputum IL8 TNFα level and the distribution of inflammatory cells.docVIP

 PAGE \* MERGEFORMAT 15 In patients with chronic obstructive pulmonary disease induced sputum IL8 TNFα level and the distribution of inflammatory cells [Abstract] Objective To compare the stable phase of chronic obstructive pulmonary disease (COPD) in elderly patients, elderly health, elderly health of smokers and non-smokers sputum IL8, TNFα levels and differences in the composition of inflammatory cells, and thus to explore IL8, TNFα , neutrophils and the relevance of smoking as well as the nature of airway inflammation in COPD. Methods 98 cases of elderly subjects were divided into 3 groups: COPD group, 38 cases, healthy smokers (HS) 30 cases of healthy non-smokers (HNS) 30 cases of induced sputum method of collecting sputum, cell sorting and counting, and use enzyme-linked immunosorbent assay (ELISA) measured in sputum supernatant IL8, TNFα concentration. Results in the COPD group sputum IL8,, TNFα , the percentage of neutrophils was significantly higher than healthy smokers and healthy non-smoking group; COPD group sputum IL8, TNFα levels and the percentage of neutrophils was significantly positive correlation (r = 0761, r = 0495); healthy smokers sputum IL  8 levels and neutrophil percentages Yicheng significant positive correlation (r = 0544). Conclusion IL8 and TNFα , and neutrophils to participate in airway inflammation in COPD smokers. [Keywords:] Chronic obstructive pulmonary disease; airway inflammation; IL  8; TNF  α ; neutrophil About 80% ~ 90% of chronic obstructive pulmonary disease (COPD) patients were smokers, but only 20% of smokers develop COPD 〔 1〕 , you are prompted for COPD susceptibility to different groups of people, their airway to the The same response to stimulation of different cigarettes. At present the view that smoking caused by abnormal airway and lung tissue inflammation is the central link in COPD pathogenesis, a variety of inflammatory cells, inflammatory mediators and cytokines involved in inflammation of the com