Indapamide lyophilized orally disintegrating tablets in the pharmacokinetics of Beagle dogs.docVIP

 PAGE \* MERGEFORMAT 11 Indapamide lyophilized orally disintegrating tablets in the pharmacokinetics of Beagle dogs [Abstract] Objective: To study the self-indapamide and commercially available lyophilized orally disintegrating tablet Indapamide tablets in Beagle dogs Pharmacokinetics and relative bioavailability behavior. Methods: 6 Beagle dogs were randomly divided for the two groups made a single oral dose of indapamide lyophilized orally disintegrating tablets and conventional tablets commercial indapamide dose administration are 5.0mg.1 weeks after the cross. determined by HPLC after administration of different time plasma concentrations. Results: Test preparation for freeze-dried indapamide made orally disintegrating tablets and reference tablets Indapamide tablets in the main pharmacokinetic parameters: peak time tmax were (1.59 + -0.04 ) h and (2.71 + -0.32) h, when peak drug concentration max were (6.10 + -0.32) and (5.89 + -0.44) g mL-1, t1 / 2 were (15.04 + -0.48) h and (14.65 + -0.73) h, AUC0 were (89.66 + -8.34) and (67.58 + -2.56) g h mL-1. Conclusion: The statistical analysis showed that freeze-dried oral self-collapse of indapamide chip solution is higher than the bioavailability of commercially available conventional tablets of indapamide. [Keywords:] indapamide; pharmacokinetics; bioequivalence; Beagle dogs [ABSTRACT] Objective: To study the relative bioavailability and pharmacokinetic of Indapamide lyophilized oral disintegrating tablets and indapamide tablets in beagle dogs.Methods: The Indapamide lyophilized oral disintegrating tablets (test) or Indapamide tablets (reference) were orally administered to 6 beagle dogs at a dosage of 5.0mg.The crossover dosing was taken in one week after the first single dose.The Indapamide concentrations in the blood samples were determined by HPLC.Results: The main pharmacokinetic parameters of the test and reference tablets were as follows: tmax ( 1.59 + -0.04) and (2.71 + -0.32) h, max (6.10