Indicators MoM values of Down syndrome screening study of the positive state of.docVIP

 PAGE \* MERGEFORMAT 7 Indicators MoM values of Down syndrome screening study of the positive state of [Keywords:] Down syndrome Normality of MoM of screening indexes for Downs syndrome [Abstract] AIM: To explore the normality of MoM values of AFP and HCG used to screen the Downs syndrome in Jiangsu province, and discuss the feasibility and effectiveness of application of SL transformation in Johnson system of distributions which is used to normalize MoM values of indexes above. METHODS: The data were obtained from the research project on birth defect intervention in Jiangsu province. SL transformation in lognormal distribution and Johnson distribution system was used to normalize MoM values of AFP and hCG in prenatal screening for Downs syndrome. RESULTS: The MoM values of AFP and HCG were both not of normal distribution. Through the lognormal distribution of MoM values, AFP was in accord with normal distribution and hCG was not. Normality of HCG MoM became better at Z = 0.31. CONCLUSION: It is suitable for the indexes of prenatal screening for Downs syndrome in our country to use SL normality transformation in Johnson system of distributions. [Keywords] Downs syndrome; prenatal screening; normality; Johnson distribution system [Abstract] Objective: To study the indicators of prenatal screening for Down syndrome in Jiangsu AFP and HCG in MoM values of normality, the distribution system and explore the Johnson family in the SL distribution of normality in these indicators of the feasibility of converting the application and effective . Methods: Data from the birth defect intervention project in Jiangsu Province study using lognormal and Johnson distribution system in the SL normality conversion method. Results: MoM values of the two indicators are not subject to normal distribution; right number MoMHCG value for the sample mean and standard deviation as a parameter, the AFP indicators of normality better, HCG is still subject to normal; Z = 0.31 when the i