Infants after cardiopulmonary bypass in blood conservation.docVIP

 PAGE \* MERGEFORMAT 16 Infants after cardiopulmonary bypass in blood conservation [Keywords:] cardiopulmonary bypass; coagulation system; congenital heart disease; infants and young children; cyanosis Postoperative bleeding is the most common cardiovascular complication of surgery, often leading to mortality and economic costs increased significantly. The total cases of cardiovascular surgery about 10% of surgical cases, but the overall Yongxue Liang Yong Xueliang accounted for 70% ~ 80%. In which bleeding is an important one of the reasons. CPB (cardiopulmonary bypass, CPB) the inevitable blood-thinning, foreign body contact, low temperature and low pressure caused by blood clotting and inflammatory factors significant changes in composition of the body had a significant impact. Compared with adults, infant and child development coagulation system is not perfect, combined with the increasing complexity of surgery, so that blood coagulation disorders in infants and young children increasingly prominent problem. In this paper, infants and young children Wai CPB period blood conservation research are summarized as follows [1]. Infants and young children characterized by a coagulation system 1.1 procoagulant component of neonatal vitamin K after birth, there is usually a lack of four kinds of vitamin K-dependent coagulation factor Ⅱ , Ⅶ , Ⅸ , Ⅹ lacking, but this situation can be corrected by vitamin K, generally 6 months after birth to adult level in early childhood, these four, the average concentration of coagulation factors were still significantly lower than that for adults. In addition, the exposure factor Ⅻ , Ⅺ , PK, HWM-K after birth, the lowest level, such as Ⅻ level was only after the birth of adults 39%, XI is approximately 49% of normal adult levels. HMW-K level in a month to reach adult levels rapidly and the remaining three kinds of concentrations of coagulation factors will be gradually rising to 6 months of age, when close to adult level, but