Insulin-like growth factor and intrauterine growth retardation.docVIP

 PAGE \* MERGEFORMAT 13 Insulin-like growth factor and intrauterine growth retardation Keywords:: insulin-like growth factor-fetal growth retardation fetal organ maturity 0 Introduction Intrauterine growth retardation (IUGR) are the birth of their gestational age and body mass is less than the average body mass of the 10th percentile person, or less than their average body mass of the two standard deviations of those. Incidence rate of about 3% to 4 %. IUGR is a major cause of perinatal death, one neonatal period and the long-term morbidity was significantly higher. in childhood than the normal physical and intellectual development of children are lagging behind. There are research suggests that IUGR and adult diabetes and cardiovascular disease has a causal link [1]. In view of the above reasons, IUGR the cause of more and more people’s attention, especially for IUGR endocrine aspects of more and more in-depth research. This article focuses on recent review of insulin-like growth factor (insulin - like growth factors, IGFs) and the relationship between IUGR research progress. 1 IGFs Salmon growth hormone in 1957 found that (growth hormone, GH) by sulfate-mediated indirect factors play its sulfate activity. The sulfate factor is the later IGFs, and since then has embarked on a IGFs research. With the the dependence of this factor in a variety of growth hormone metabolism and not to be anti-insulin antibody blocked the activity of understanding, collectively known as growth-promoting factor (somatomedins). in the study of its chemical structure, at the same time, purification of the two kinds of the same material and promote growth factor-A and promote growth factor C. Because of their structural similarity with insulin is called insulin-like growth factor, including IGF-Ⅰ and IGF-Ⅱ . IGF-Ⅰ with the previous growth-promoting factors A and C are identical The [2]. IGF-Ⅰ and IGF-Ⅱ by 70 amino acids and 167 amino acids, molecular mass 7647ku. The human se