Interferon- +874 polymorphism and chronic obstructive pulmonary disease.docVIP

 PAGE \* MERGEFORMAT 11 Interferon- +874 polymorphism and chronic obstructive pulmonary disease [Abstract] Objective: To study the IFN- +874 gene polymorphism in Chinese Han population in Inner Mongolia, chronic obstructive pulmonary disease (COPD) patients in the frequency distribution and to analyze its relationship with the pathogenesis of COPD. Methods: Case-control research methods survey information, PCR-SSP assay IFN- +874 site in case group and control group, the frequency of various genotypes and allele frequencies. Results: COPD group IFN- +874 bit point of AA, AT, TT genotype frequencies were 82.8%, 17.2% and 0.0%; control group AA, AT, TT genotype frequencies were 63.4%, 33.3%, 3.1%; COPD group IFN- locus +874 A, T allele frequency was 91.4%, 8.6% in the control group was 80.3%, 19.7%; COPD group locus IFN- +874 AA genotype and A allele frequencies were higher in the control group, the difference was statistically significant (P lt;0.05). CONCLUSION: IFN- +874 polymorphism and the Han population in Inner Mongolia in the pathogenesis of COPD. [Keywords:] Chronic obstructive pulmonary disease; interferon-; gene polymorphism Abstract Objective: To explore the frequency distribution of genetic polymorphism of interferon- +874 (IFN- +874) in the patients with chronic obstructive pulmonary diseases (COPD) among Han nationality in Inner Mongolia and to analyze the correlation between genetic polymorphism of IFN- +874 and the incidence of COPD. Methods: The case-control method was employed to carry out a questionnaire investigation of the related data and genotype and allele frequency of IFN- +874 in the COPD group and the control group was determined with PCR-SSP. Results: The genotype frequency of IFN- +874 AA, AT and TT was 82.8%, 17.2% and 0.0%, respectively, in COPD group and that in the control group was 63.4%, 33.3% and 3.1%, respectively. Allele frequency of IFN- +874 A and T was 91.4% and 8.6% in COPD group, and that in the control group w