Intracellular Ca2 + concentration and CaMKrole in learning and memory research progress and impact of.docVIP

 PAGE \* MERGEFORMAT 16 Intracellular Ca2 + concentration and CaMKrole in learning and memory research progress and impact of [Keywords:] intracellular Ca2 + concentration in learning and memory CaMK Giacobini synaptic plasticity theory proposed that synapses are not static, fixed structure Bliss In 1973 the first discovery in the anesthetized rabbits, a short string of high frequency stimulation (tetanic stimulation of afferent fibers through pathways in the hippocampus dentate gyrus granule cells induced for 10 hours or more of the population spike and population excitatory postsynaptic potential amplitude increased ease of synaptic transmission performance phenomenon, that is, long-term potentiation (1ong-term potentiation, LTP) LTP is a phenomenon and made synaptic model of memory [1]. Greenough training through the maze of the occipital cortex of rats after the experiment found that pyramidal cells in the formation of new synapses [2]. The level of research in learning and memory synapses provides an ideal model and cellular basis. Synapse is the site of memory storage. The human nervous system exists in thousands of synapses may be stored large amounts of information. LTP studies have shown that presynaptic and postsynaptic Ca2 + concentration in neurons were associated with LTP, the level of induction and maintenance related. Some researchers have envisaged the possibility that each synaptic protein interaction through the physical and biochemical processes locally can promote the long-range information storage, which constitute the molecular basis of memory. Lisman there is a vision as a “molecular switch “of the kinase in the learning process is activated by phosphorylation and activation of the kinase is also able to catalyze its own phosphorylation, kinase molecules so that even after the end of the study to maintain long-lasting activation [3]. large number of studies found that calcium / calmodulin-dependent protein kinase (calcium / cal