Intra-bone marrow injection of hematopoietic stem cell transplantation research and application.docVIP

 PAGE \* MERGEFORMAT 29 Intra-bone marrow injection of hematopoietic stem cell transplantation research and application Abstract injections of bone marrow hematopoietic stem cell transplantation to promote the homing of HSC. In recent years, a large number of animal experiments have confirmed the different sources of donor cells in the bone marrow cavity through the injection can be effective in homing and implantation of bone marrow, the rapid reconstruction of receptors of hematopoietic and immune function, reduce GVHD, induced by allogeneic organ transplantation immune tolerance, increased receptor survival. In this paper, the technology in the bone marrow transplant, cord blood transplantation, research and other biological characteristics of HSC’s role as well as the prospect for clinical application were reviewed. Keywords: Bone marrow injections Progress of Research and Application on Hematopoietic Stem Cell Transplantation by Intra-bone Marrow Injection - Review Abstract The purpose of hematopoietic stem cell transplantation by intra-bone marrow injection (IBM-HSCT) is to facilitate the homing of HSC. It has been recently proven in many animal experiments that different kinds of donor cells could efficiently home and engraft into the bone marrow by IBM-HSCT, which led to the rapid hemopoietic and immune recovery of recipients, preventing the development of GVHD, inducing the donor-specific tolerance in allogeneic organ transplantation, and promoting the survival rate of recipients. In this review, the effect of IBM-BMT and IBM-UCBT, the application of IBM injection technique in the study on HSC ‘s biological characteristics, and its prospect for clinical HSCT were sumarized. Keywords: intra-bone marrow injection; hematopoietic stem cell transplantation; bone marrow transplantation; cord blood transplantation Hematopoietic stem cell transplantation (hematopoietic stem cell transplantation, HSCT) after 40 ye