Intrauterine infection in pregnant syphilis and factors related to diagnosis and treatment of.docVIP

 PAGE \* MERGEFORMAT 11 Intrauterine infection in pregnant syphilis and factors related to diagnosis and treatment of [Keywords:] diagnosis and treatment of intrauterine infection in pregnant syphilis By the pale spirochetes of syphilis (Treponema Pallidum, TP caused by highly contagious sexually transmitted disease during pregnancy can cause intrauterine infection, resulting in miscarriage, stillbirth, premature delivery or birth child of congenital syphilis. About 2 / 3 of untreated pregnant women infected with syphilis can be transmitted to the fetus, stillbirth and neonatal death is the most serious outcome of pregnancy. In China, over the past decade the incidence of syphilis in pregnancy, increasing year by year [1 2], in the United States and the Russian Federation also has a higher incidence of rate [3]. Therefore, the study of syphilis during pregnancy, the incidence of congenital syphilis prevention, to improve the quality of the population is of great significance. 1. Intrauterine transmission mechanism and influencing factors Pregnancy, syphilis can lead to intrauterine transmission through the placenta, research suggests that infection of the first TP decidual cells derived from the mother, then by the invasion of adjacent villi villi gap and eventually infected the fetus, including interstitial villus Hofbauer cells (HC) play an important role. HC virus infection, due to the role of chemokines, can penetrate down into the fetal circulation [4]. Zhu et al [5] of the Chinese Han population DC SIGN gene polymorphism, the results show that DC SIGN gene polymorphism in a variety of pathogens and their spread has an important role. HC and DC SIGN gene in congenital syphilis, the mechanism of intrauterine vertical transmission plays an important role. Intrauterine infection and maternal disease course and duration of treatment during pregnancy is related to the mother during pregnancy blood RPR positive rate, TP and TP IgM titer level of