Iron bars hammers extract on rat adjuvant arthritis study.docVIP

 PAGE \* MERGEFORMAT 8 Iron bars hammers extract on rat adjuvant arthritis study Of: Zhang Yiwei Lin Dong Fu Xueyan piano [Abstract] Objective To investigate the iron bars, hammers extract on adjuvant arthritis and its mechanism. Methods rat adjuvant arthritis model was an iron bar hammer extract on rat paw swelling and serum leukocyte interleukin-1 (IL-l) and tumor necrosis factor - @ (TNF-@) content. Results crowbar hammer extract 40mg/kg treatment group and positive drug could significantly reduce the rat paw edema model degree (P lt;0.05) and IL-l (P lt;0.05) and TNF-@ (P lt;0.05) content. Conclusions crowbar hammer extract has anti-inflammatory effect, its mechanism and reduce the IL-l and TNF-@ the level of . [Keywords:] iron bars, hammers cytokine adjuvant arthritis Iron bar hammer is Ranunculaceae Aconitum genus Aconitum flavum (Acontium flavum Hand-Mazz) of the root, gas specific, Ma Weixin the tongue, toxic. As Shaanxi, Gansu, Ningxia and other provinces of a wider application folk medicine, according to lt;lt;Shaanxi Chinese Herbal Medicinegt;gt; records, the drug may “stasis, rheumatism, pain, swelling and sepsis, to rot myogenic, bleeding, treatment of bruises, rheumatoid arthritis, low back pain LO injury, malignant sore boils, swelling of unknown toxicity, frostbite, snakebite, “[1]. modern pharmacological research found that the drug has anti-inflammatory, narcotic analgesic, anti-tumor effects [2], but its anti-inflammatory effect mechanism is not fully understood, for this study, iron bars, hammers extract on adjuvant arthritis treatment, and further analysis of the mechanism. 1 Materials 1.1 Animals Male SD rats of clean grade, weighing 180 ~ 220g, were purchased from Ningxia Medical University Experimental Animal Center, Animal Production License No.: SCXR (Ning) 2005-001, free feeding and drinking water, to maintain room temperature (20 + -2 ) , humidity (50 + -2)% 1 week adaptive feeding experiment. 1.2 Reagents and ma