Ischemic postconditioning on myocardial ischemia-reperfusion rat heart after hemodynamic improvement of.docVIP

 PAGE \* MERGEFORMAT 10 Ischemic postconditioning on myocardial ischemia-reperfusion rat heart after hemodynamic improvement of On: All Southern Tigers Zheng Yang Yu Hong Ying Zhao [Abstract] Objective postconditioning (ischemic postconditioning, IPO) of normal isolated rat myocardial reperfusion to improve hemodynamics. Methods in normal isolated rat heart Langendorff perfusion method, heart stopping 30 min reperfusion , 60 min reperfusion copied into the reperfusion injury of myocardial ischemia (I / R) model, we determined hemodynamic parameters and 30 min reperfusion in coronary effluent lactate dehydrogenase (LDH), creatine kinase (CK) content. end of the experiment and isolated left ventricular cross into five, into an area of TTC in the determination of myocardial infarction. Results of isolated myocardial ischemic postconditioning significantly improved after the intervention of reperfusion on left ventricular systolic pressure (LVSP ) and left ventricular pressure maximal rate of rise (+ dP / dtmax) and other indicators of blood rheology, and significantly reduced the LDH and CK after reperfusion the release and ventricular arrhythmias; the same time after the intervention to adapt to reduced myocardial infarct size (47.3%, 29.5%). Conclusion postconditioning on ischemic reperfusion in isolated rat hemodynamics after the injury has a clear role to improve the prevention of myocardial ischemia reperfusion injury. [Keywords:] postconditioning; isolated rat heart; ischemia-reperfusion injury Acute myocardial infarction (AMI), AMI reperfusion therapy is the treatment most effective treatment. But subsequent reperfusion may offset the benefit of reperfusion therapy. To reduce reperfusion injury, can improve the prognosis of patients. Ischemic postconditioning (ischemic postconditioning, IPO) that the start of reperfusion, immediately give one or more short-term repeated myocardial ischemia and reperfusion, can improve on before the occurrence of