Isoflavones subacute aging mice on antioxidant effect of.docVIP

 PAGE \* MERGEFORMAT 9 Isoflavones subacute aging mice on antioxidant effect of Of: a Li-Hua Song Zhang Chunhua Zheng Wang Qiaoguo to Lina Li Haiju [Abstract] Objective: To investigate the isoflavones on antioxidant capacity in aging model mice. Methods: The preparation of D galactose aging mice were divided into normal control group, model group, positive control group, high and low dose group, Detection of serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels. Results: isoflavones significantly decreased serum MDA aging mice level, while increasing SOD and GSH-PX activity level. Conclusion: Flavonoids of Pueraria subacute aging mice with anti-oxidation. [Keywords:] isoflavones; antioxidant; subacute aging model D galactose induced subacute aging model changed significantly because of their age, model stability, anti-aging research is widely used. Is generally believed, D galactose metabolism caused by peroxidation increased so that the body caused by aging of its reaction important factor. isoflavones (Puerarin flavonoid) system is one major component of Pueraria, Pueraria only contained in the lt;lt;Shen Nong’s Herbal Sutra “gt;, for the legume Pueraria lobata and the dry root, fever with Jie Ji, Sheng Jin Touzhen, Sun antidiarrheal effect. Pueraria main active ingredients of isoflavones and daidzein. pharmacological effects of isoflavones are more widely used clinically for cardiovascular and cerebrovascular diseases, retinal diseases, and so has a good effect. Vitro that [1-4], isoflavones have strong antioxidant capacity, can significantly remove OH, DPPH · radical, can be used to prevent oxidative damage to membrane. In this study, D galactose induced subacute aging model to observe the isoflavones on aging mice antioxidant ability. 1 Materials and methods 1.1 Extraction of isoflavones [5] taking herbs Pueraria crushed into meal, set round bottom flask, add 95% ethanol 1 h, filtrati