Intravascular drug-eluting stent preparation and application of research.docVIP

Intravascular drug-eluting stent preparation and application of research.doc

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Intravascular drug-eluting stent preparation and application of research

 PAGE \* MERGEFORMAT 29 Intravascular drug-eluting stent preparation and application of research Keywords: drug-eluting vascular stent restenosis Review With the endovascular stent extensive application brought by the restenosis after stent implantation is increasingly subject to attention. Studies have shown that cause in-stent restenosis (ISR) different factors, such as vascular intimal injury, thrombosis, stent adjacent vascular remodeling, inflammation, healing, genes and so on, but the currently accepted formation mechanism of ISR In addition to the vessel wall in the recoil after dilatation and thrombosis, the injury-induced vascular smooth muscle cells (VSMC) proliferation and excessive migration to the intima plays a key role [1]. In recent years, the mechanism for a variety of ISR has developed a variety of drug-eluting stents. Drug-eluting stents, endovascular stent that is coated with a layer of drug films for drug release to achieve long-lasting treatment and prevention purposes. This metal stent surface is coated with a polymer, and on this basis, combined with therapeutic drugs, the drug-coated stent after intravascular local drug can slow the release of the vessel, and through different mechanisms play a role, so as to achieve the treatment and prevention purposes. By drug-eluting stent for the preparation method, type and characteristics of the research progress and effectiveness in clinical applications and problems to be solved are reviewed. Preparation of a drug-eluting stent Drug-eluting stents mainly by the stent, matrix and drug three parts. Main body frame, components are mostly stainless steel or alloy, but also for biological materials. Matrix is used that can be bio-degradable polymers prepared from the multi-multi-use polymer materials with good biocompatibility in order to reduce the incidence of inflammation in vivo with the polymer degradation of the drugs can carry was slowly released. Therefore, the polym

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