Kechuanning of bronchial asthma on lung tissue of IL-5mRNA expression_0.docVIP

 PAGE \* MERGEFORMAT 15 Kechuanning of bronchial asthma on lung tissue of IL-5mRNA expression OF: MEDICINE IN, IN TRADITIONAL, Wang [Abstract] Objective To observe Kechuanning on lung tissue of rats with bronchial asthma Interleukin -5 (IL-5) mRNA expression. Methods 40 SD rats were randomly divided into normal group, model group, high dose Kechuanning group (27 g crude drug / kg body weight), Kechuanning low dose group (13.5 g crude drug / kg body weight), Guilongkechuanning the control group (0.41 g / kg body weight), n = 8. In addition to the normal group In addition, to OVA sensitized and inhalation provocation prepared rat model of bronchial asthma, the treatment groups were from the 1st of provocation of asthma (3 weeks of modeling) to death before the daily oral administration to stimulate and administration rats were killed after 4 weeks. by RT-PCR, the expression of IL-5mRNA by HE staining of lung and tracheal pathology. Results Compared with normal rats, the thickness of bronchial wall and smooth muscle, eosinophils , lymphocytes and lung tissue IL-5mRNA expression was significantly increased (P lt;0.01), compared with model group, treatment groups significantly reduced the thickness of bronchial wall and smooth muscle, eosinophils, lymphocytes, and IL-5mRNA expression (P lt;0.05 or P lt;0.01). Conclusion cough would rather reduce the lung tissue IL-5mRNA expression, inhibition of eosinophil infiltration in the airway, accumulation and activation, to reduce airway inflammation in asthma. [Keywords:] Kechuanning, bronchial asthma, IL -5, rat Keywords:: Kechuanning, bronchial asthma, IL-5, rat Bronchial asthma is the eosinophil (EOS), mast cells and lymphocytes, and other inflammatory cells involved, IL -5 (IL-5), tumor necrosis factor - @ (TNF-@) and other cytokines mediated chronic airway inflammation [1]. Kechuanning research group after years of clinical observation for the screening of the efficiency side, to further elucidate the