Ketoprofen hydroxypropyl cyclodextrinβgel Preparation and percutaneous penetration.docVIP

 PAGE \* MERGEFORMAT 9 Ketoprofen hydroxypropyl cyclodextrinβgel Preparation and percutaneous penetration [Abstract] Objective To screen  β  ketoprofen hydroxypropyl cyclodextrin (KP  HP  β  CD) gel the best prescription, compare the gel and ketoprofen (KP) free drug-gel In vitro skin permeability to explore the inclusion complex as a carrier of the impact of percutaneous absorption of KP. Approach to high temperature levels change as the stability of the KP index, using the orthogonal experimental design to establish the best prescription. A modified dual-chamber infiltration pond as in vitro skin penetration test device to measure liquid KP receiving the accumulated through drug loading and retention within the skin dose. Results pH of 7.0 for every 100 g propylene glycol cosolvent gel dosage of 20 mL, anti-oxidants NaHSO3 of 0.3 g, the inclusion complex gel viscosity is moderate, the best thermal stability. Inclusion gel transdermal delivery process meets the zero-order release kinetics, as compared with the free KP gel, the former much slower rate of drug through the skin, transdermal 24 h, retention of drugs in the skin of about 2.5 times the latter. Conclusion KP  HP  β  CD inclusion complex gel formulation design is reasonable, the nature of stability. To inclusion, KP carrier, carbopol gel as a matrix with the promotion of the role of drugs into the skin. [Keywords:] ketoprofen gel inclusion complex orthogonal percutaneous penetration Ketoprofen (ketoprofen, ketoprofen, KP) for non-steroidal anti-inflammatory analgesic drugs, with a clear anti-inflammatory and antipyretic effect, but its solubility smaller, less stable, oral administration of a gastrointestinal tract adverse reaction.  β  writer hydroxypropyl cyclodextrin (hydroxypropyl  β  cyclodextrin, HP  β  CD)-based molecules, made of hydroxypropyl ketoprofen   β  cyclodextrin inclusion complex (KP  HP  β  CD), so that dissolution and stability pro