Lipid regulating hyperlipidemia Kang rabbit liver LDL-R mRNA levels of experimental study.docVIP

 PAGE \* MERGEFORMAT 8 Lipid regulating hyperlipidemia Kang rabbit liver LDL-R mRNA levels of experimental study [Abstract] Objective through the establishment of New Zealand rabbits with hyperlipidemia model to explore the level of liver low density lipoprotein receptor gene and hyperlipidemia in the formation of relationships. Methods (1) the establishment of hyperlipidemia rabbit model; (2) In situ hybridization to detect the level of liver low density lipoprotein receptor gene. Results (1) successfully established rabbit model of hyperlipidemia; (2) lipid-kang can effectively reduce the blood lipid levels prescription, and can effectively increase the level of liver low-density lipoprotein receptor gene. Conclusion Kang prescription can activate the liver lipid membrane LDL-R gene expression, so that LDL-R activity was enhanced to accelerate the decomposition of lipoproteins, effectively regulate blood lipid levels. [Keywords:] hyperlipidemia; low-density lipoprotein receptor; gene expression Study the effect of Zhikang on blood-lipid and low density lipoprotein receptor mRNA in rabbit [Abstract] Objective To study the immune mechanism of Zhikang to control the development of hyperlipidemia.Methods (1) To set up hyperlipidemia models of New Zealand rabbits. (2) To observe the pathological changes in liver. (3) To study the effects of Zhikang by detecting the levels the gene of low density lipoprotein receptor through ISHH (in situ hybridization histochemistry). Results (1) A hyperlipidemia model was successfully established by using high-fat diet in New Zealand rabbits. (2) Zhikang can effectively reduce the level of lipids and it can increase the levels of the gene of low density lipoprotein receptor. Conclusion Zhikang can effectively reduce the level of lipids and improve the condition of atherosclerosis, at the same time, it can effectively regulate the immune functions on the levels of gene of low density lipoprotein receptor. [Keywords: