lipoic acid on STZ-induced diabetes blood glucose blood lipids and oxidative stress regulation.docVIP

 PAGE \* MERGEFORMAT 12 lipoic acid on STZ-induced diabetes blood glucose blood lipids and oxidative stress regulation [Abstract] Objective To investigate the antioxidant lipoic acid on diabetic rats @ lipids, glucose and the regulation of oxidative stress. Methods 50 Wistar rats were randomly divided into control group, diabetes group, @ lipoic acid treatment of low dose group (LLA , middle dose group (MLA, high-dose group (HLA. application of streptozotocin (STZ intraperitoneal injection modeling. the control group, diabetic group treated with normal saline every 2 ml / d, LA intervention group were given LA 30 , 60,120 mg kg-1 d-1 injected a total of 4 w. measured body weight, blood glucose, glycated hemoglobin (HbA1c, blood lipids and liver malondialdehyde (MDA, total antioxidant capacity (T AOC level. Results In diabetic triglyceride (TG, total cholesterol (TC, low-density lipoprotein (LDL, HbA1c, and liver MDA levels were significantly higher and the high-density lipoprotein (HDL, T AOC was significantly lower @ lipoic acid intervention subgroups plasma TG, TC, LDL, HbA1c, and diabetes than those in liver MDA levels were significantly decreased, while HDL, T AOC increased significantly, the difference was statistically significant (P lt;0.05, HLA, and MLA blood glucose in diabetic rats was significantly decreased (P lt;0.05. Conclusion @ lipoic acid can significantly improve the diabetic state of the “toxic glycolipid” and oxidative stress. [Keywords:] @ lipoic acid, type 2 diabetes, dyslipidemia, oxidative stress, Wistar rats Glucose metabolism in patients with diabetes, while often associated with lipid metabolism, lipid metabolism and the study confirmed that the body increase in lipid peroxidation and the formation of atherosclerosis is closely related to (1). @ LA is a mitochondrial enzyme complex A secondary factor that can eliminate free radicals, restore and increase the level of other antioxidants in vivo, lower levels of inflammatory