Lipopolysaccharide on rat hypothalamic paraventricular nucleus GABABR1 activation of neurons in.docVIP

 PAGE \* MERGEFORMAT 4 Lipopolysaccharide on rat hypothalamic paraventricular nucleus GABABR1 activation of neurons in [Abstract] Objective: To evaluate the rat hypothalamic paraventricular nucleus (PVN)  aminobutyric acid B receptor subunit 1 (GABABR1)-positive neurons on lipopolysaccharide (LPS) stimuli. Methods: Rats were intraperitoneally injected LPS immune-stress model, the same amount of saline injected control group, using immunofluorescence double labeling and laser confocal microscope to observe the rat hypothalamic paraventricular nucleus neurons in Fos and GABABR1 marks as well as they are in the same neurons whether there were marked. Results: The intraperitoneal injection of LPS can be expressed in rat PVN the number of Fos neurons was significantly higher, and the inside part of the PVN neurons were Fos and GABABR1 simultaneously double-labeled, double-labeled neurons accounted for about Fos neurons 30% of the total GABABR1 24%. Conclusion: The next part of the hypothalamic paraventricular nucleus GABABR1 neurons involved in the LPS-induced immune stress response, they may be the next hypothalamus   pituitary adrenal axis play an important role in the regulation. [Keywords:] lipopolysaccharide genes Fos γ  aminobutyric acid B receptor subunit 1 (GABABR1) fluorescent antibody technique hypothalamic paraventricular nucleus (PVN) stress 0 Introduction Lipopolysaccharide (LPS) into the body’s immune cells can induce secretion of inflammatory cytokines, stimulate the body’s immune stress response, animals, injection of LPS is to study the immune system and nervous system, the relationship between the commonly used model [1]. γ  aminobutyric acid (GABA) is an important central nervous system inhibitory neurotransmitter, by ion receptor GABAAR and metabotropic receptors GABABR role [2-3]. GABABR including GABABR1 and GABABR2 two subtypes, which is a receptor GABABR1 The main part of [2]. the body’s neuroendocrine hypothalamus and the aut