Mao Dan enema compound toxicity irritation studies.doc

 PAGE \* MERGEFORMAT 6 Mao Dan enema compound toxicity irritation studies [Abstract] Objective To observe the effects of Mao Dan enema security. Methods animal experiments, to detect and observe the effects of Mao Dan Enema of the general state of experimental animals, behavior, mucosal tissue. Results Dan enema compound animal hair-free acute toxicity, no irritant effect on the intestinal mucosa. Conclusion The compound treatment of pelvic inflammatory disease Mao Dan enema safe. [Keywords:] Dan enema compound hair irritation test of acute toxicity test Dan enema compound hair is my many years of hospital clinical director of gynecology Lu Shuqiong summary of prescription anti-inflammatory Sanjie their effectiveness for the treatment of pelvic inflammatory disease. To prove the safety of its clinical use, according to lt;lt;new drug approval proceduresgt;gt; in relation to Chinese medicine part of the experimental design. for acute toxicity, irritation studies, methods and results are presented as follows [1]. 1 Mao Dan enema compound acute toxicity test 1.1 The purpose of the experiment a second dose of Compound Dan enema enema hair, stomach, observe performance and mortality of animals to see enema Dan compound gross toxicity, and for other clinical trials have provided the basis for dose selection . 1.2 mice experimental animal health, weight (20 + -2) g, male and female, a total of 20 (Zhanjiang, Guangdong Province, medical schools by the animal room provided). Dan experimental drug compound 1.3 gross enema preparations by the Chinese Medicine Hospital, Zhanjiang City Room of the first batch number: 100415. 1.4 experiments the rats were randomly divided into two groups, 10 rats in each group, male and female, divided into two groups and fed enema group, the amount of each drug were 1mL (containing crude drug content was 0.55g, equivalent to 27.5g / kg, for the clinical use of drugs after administration of