MAOA TPH gene and schizophrenia and depression.doc

 PAGE \* MERGEFORMAT 20 MAOA TPH gene and schizophrenia and depression Author: WANG Cong-Hui Shi Lu in line [Keywords:] monoamine oxidase A; tryptophan hydroxylase; gene polymorphism; schizophrenia; Depression [Keywords:] monoamine oxidase A; tryptophan hydroxylase; gene polymorphism; schizophrenia; Depression Pedigree investigation of mental illness, twins investigation and genetic epidemiological survey data show that some mental illness, such as: Alzheimer’s disease (Alzheimer’s disease, AD), schizophrenia, bipolar psychosis and other significant family aggregation, indicating genetic factors play a role in the pathogenesis. Biochemical studies have shown that neurotransmitters, in particular monoamine neurotransmitters, neurotransmitter transporter, receptor studies, in elucidating the mental illness play a very significant role in 5-HT (5HT) is an important neurotransmitter in vivo, with a variety of mental diseases is closely related to tryptophan hydroxylase (TPH), monoamine oxidase A (MAOA) is a 5HT synthesis and metabolism of key enzymes, the corresponding relationship between genes and mental illness at home and abroad the concern of researchers, In this paper, MAOA, TPH gene and the relationship between mental illness make a review. 1 gene structure and polymorphism MAOA gene regulation in the synthesis of the short arm of X chromosome Xp11.23 ~ 11.4 on 1991, the use of monoamine oxidase A and B, cDNA-specific fragment from the X chromosome gene library to isolate about 60 kb of the monoamine oxidase A and B genes [ 1], these two genes have 15 exons and their intron exon organizations were also identical. Hotamisligil et al [2] in 1991 found that in MAOA coding region of the EcoR Ⅴ , Fnu4H Ⅰ restriction site polymorphism in the 5 ‘end non-coding region found in Msp Ⅰ restriction site polymorphism, the authors believe that MAOA gene in part through the non-coding, regulatory elements determine activity. Balck, etc. [3] reported that MAOA first