Marine biological source of drug lead compounds in research.docVIP

 PAGE \* MERGEFORMAT 26 Marine biological source of drug lead compounds in research [Abstract] active substances in marine organisms rich in this article right at home and abroad the past three years, isolated from marine organisms extract to the terpenoids, and glycosides were summarized, and its research trends are prospected. These new terpenoids found widely distributed in the algae, corals, sponges and some marine fungi and other marine species, mainly monoterpene, sesquiterpene, diterpene, triterpene structural type exist; and glycosides in the seaweed, sponges , sea cucumbers, starfish and other marine life found in a large majority of lipid glycosides, steroidal glycosides, terpene glycosides pattern exists. [Keywords:] marine terpenoids glycosides biological activity [Abstract] Marine organism show some important biological activities. This paper reviews terpenoids and glycosides from marine organism at home and abroad since 2005, and provides scientific evidence for reasonable exploitation and application. Terpenoids are mainly occurred on marine algae, coral, sponge and some fungi by monoterpene, sesquiterpene, diterpene and triterpene. And glycosides with structures of lipid, steroid and terpenoid are distributed to marine algae, sponge, sea cucumber and starfish. [Keywords:] Marine organism; terpenoid; glycoside; bioactivity The ocean is the source of life, due to the particularity of the marine environment, with high-pressure, low-nutrition, low-temperature (especially deep sea), no illumination, as well as local high temperature, high salt and extreme life, the environment, marine organisms to adapt to the ocean’s unique living environment, the inevitable created a marine life has a unique metabolic pathway and genetic background, must also have a new, in many terrestrial organisms has not been discovered in the new structure types and specific bioactive compounds. Terpenoids are a class of natural hydrocarbons, its molecules with isoprene