Marine sources of fungus A f 11 indole-dione piperazines constituents of anti-tumor activity of.doc

 PAGE \* MERGEFORMAT 19 Marine sources of fungus A f 11 indole-dione piperazines constituents of anti-tumor activity of Author: Wen-Ying Zhao Zhang Yapeng Tianjiao Fang Yuchun Liu Hongbing Zhu Qian-Qun Gu, Wei-Ming Zhu Abstract of marine origin with anti-tumor activity of fungal A  f  11 in the active secondary metabolites have been studied, using active tracking method from the ethyl acetate extract were isolated 7 with indole base 2 ketone piperazine derivatives, according to the spectral characteristics of compounds and physical-chemical properties were identified as cyclo  L  tryptophyl  L  proline (1), N  Prenyl  cyclo  L  tryptophyl  L  proline (2), tryprostatin B ( 3), demethoxyfumitremorgin C (4), fumitremorgin C (5), cyclotryprostatins B (6) and fumitremorgin B (7), in which compound 2 as a new natural product. The use of Lis amine rhodamine law, seven anti-tumor activity of compounds were carried out a preliminary evaluation. Keywords: marine sources of fungal indole-dione piperazine anti-tumor activity Studies on the indolyl diketopiperazine analogs produced ABSTRACT To investigate the antitumor secondary metabolites of marine  derived fungal A  f  11. Seven indolyl diketopiperazine compounds were isolated with bioassay  guided separation procedure. The structures of these compounds were determined through extensive analysis of 1D and 2D  NMR data. Their antitumor activities against K562 cell lines were preliminarily evaluated by the lissamine rhodamine B method. Compound 2 was a new natural product. KEY WORDS Marine  derived fungus; Indolyl diketopiperazine compounds; Antitumor activity Because of the particularity of the marine environment, giving the fungus living in the ocean the physical traits and genetic background of terrestrial fungi with significant differences, so fungal metabolites from marine sources in the search for effective anti-cancer lead compounds caused by domestic