Mechanical ventilation led to the mechanism of lung injury.doc

 PAGE \* MERGEFORMAT 26 Mechanical ventilation led to the mechanism of lung injury Mechanical ventilation is to maintain anesthesia and intensive treatment must be a supplementary measure, while the mechanical ventilation induced lung injury (VILI) is the most important in this process complications, easy to induce inflammatory response syndrome (SIRS) and multiple organ failure (MSOF) , although the level of clinical treatment and care are rising, but the mortality rate of patients with acute lung injury remains high, and most of the patients died of multiple system organ failure. The current mechanism of occurrence of VILI was not clear, but numerous studies suggest that mechanical ventilation not only led to structural damage in lung tissue and lung tissue caused by “biological injury” that led to pneumonia and mechanical ventilation increase inflammatory response, neutrophil infiltration, bronchial alveolar space inflammatory mediators in the lavage fluid increased, its mechanism is a combination of channels and signal transduction pathways caused by a common role. Mechanical force or trigger the lung by activating the membrane stretch-sensitive cation channel, through the structural changes in the cytoskeleton, membrane-associated molecular conformation changes in the direct mechanical signals into the cell, and then activate the intracellular signal transduction pathway, by regulating the transcription factor, protein kinase activation and protein phosphorylation level of a variety of mechanisms, and further induce a large number of pulmonary inflammatory factor production, local inflammation reaction-diffusion, the release of inflammatory mediators in systemic circulation results in systemic inflammatory response, and the loss of immunity Persistent inflammation of the injury, the patient through a series of mechanisms to promote the development of multi-system inflammatory response syndrome (SIRS) and multiple organ failure (MSOF), but