Mechanism of diabetic wound healing progress.doc

 PAGE \* MERGEFORMAT 19 Mechanism of diabetic wound healing progress [Abstract] Wound healing is a complex biological process is inflammatory cells and repair cells, extracellular matrix and cytokines and other factors involved and the high degree of coordination, the complex process of mutual regulation. Diabetic patients susceptible to skin damage, injury delayed wound healing or nonunion, a clinical solved the difficult and hot. In recent years, diabetic wound healing mechanism of rapid progress, the main focus in the signaling pathway, angiogenesis, NPY, advanced glycation end products , apoptosis and matrix metalloproteinase and so on. This paper thus reviewed. [Keywords:] diabetes, healing, wound With the social and economic development around the world, living standards, changes in the diet, increasing pace of life and less stress and more dynamic way of life and many other factors take the global incidence and prevalence of diabetes, the rapid growth of diabetes has become the cancer, cardiovascular disease after the third serious threat to human health from chronic diseases. diabetic patients susceptible to skin damage, injury is often recurrent, delayed healing, the formation of refractory ulcer refractory. Thus, the treatment of diabetic ulcers is a clinical one of important issues need to be resolved. With the recent development of molecular biology and other disciplines, in diabetic wound healing mechanisms are becoming increasingly in-depth research, focusing on signaling pathways, angiogenesis, NPY, advanced glycation end products, apoptosis and matrix metalloproteinase and so become a hot spot of research. 1 signaling pathway Wound healing requires a variety of cells, cytokines and extracellular matrix and other factors to participate. Cytokines by various factors interact to jointly coordinate to form a complex biological networks. Any kind of cytokines may lead to wound is not the lack of more or delayed healing. At the same t