MATLAB-based pharmacokinetics of experimental data processing and parameter estimation.docVIP

 PAGE \* MERGEFORMAT 5 MATLAB-based pharmacokinetics of experimental data processing and parameter estimation [Keywords:] pharmacokinetics;,, experimental data processing;,, MATLAB;,, evaluation,,,,, Abstract: This paper describes the pharmacokinetics of MATLAB in the experimental data dealing with the basic method and the use of MATLAB for double-exponential model fitting with the EXCEL software commonly used double-exponential model fitting and parameter solving the convenience, accuracy evaluated. Keywords: pharmacokinetics; experimental data processing; MATLAB; Evaluation Pharmacokinetics in clinical pharmacology, pharmacy, toxicology and other scientific professional basis for drug design, formulation of reform, rational use of drugs, etc. have a direct guiding significance. How to correctly handle the experimental data, as well as choosing the right approach is to convey accurately the key to the process of pharmacokinetics to clinical medicine and drug design to provide a reliable basis. Most of the drug pharmacokinetics broadly in line with two-compartment model, the principle is that the human body is divided into two central compartment and peripheral compartment room, the elimination of the main central room around the room without regard to the elimination, and Suppose the exchange of drug absorption and elimination is a process. A model and parameters Two-compartment pharmacokinetic model [1] equation: C = Ae-α t Be-β t where C indicated that blood concentration, t represents time, A, B, α , β , said the constant coefficient. Two-compartment model of the other parameters calculated were: ① drug distribution phase half-life: t1 2α = 0.693 α ② drug elimination half-life: t1 2β = 0.693 β ③ drug from peripheral compartment to the central room of the distribution of rate constants: k21 = Aβ Bα A B ④ drug central compartment elimination rate constant: k10 = αβ k21 ⑤ drugs central compartment to peripheral compartment distribution of rat