Mechanism of UV on the skin Progress.docVIP

 PAGE \* MERGEFORMAT 9 Mechanism of UV on the skin Progress Of: Shao-Ping Yang Shiji Hai Liu Junli Liu Yongfu [Keywords:] Progress in Mechanism of UV skin Skin is the body’s largest organ, is ultraviolet (UV irradiation of the organ most vulnerable to injury. UV radiation can cause skin damage, caused by skin erythema, light aging. Ultraviolet radiation skin changes in a series of cytokines, cell signaling mediated changes and apoptosis. longwave and medium wave ultraviolet (UVA and UVB can affect the skin and produce a variety of biological effects, this article will cellular level and gene level UV irradiated skin on a variety of biological effects are reviewed. An ultraviolet radiation induced cellular effects of skin 1.1 keratinocytes (KC In the epidermis, KC largest number, KC in by ultraviolet radiation, will cause the skin micro-environment changes, you can release of many cytokines, these cytokines involved in mediating a number of inflammatory and immune responses [1]. IL-1 secretion by the KC, IL-1 under normal circumstances, the distribution in the stratum corneum, UV irradiation, IL-1 in epidermal basal layer and increase in the number. IL-1 is the KC induction factor for keratin 6 (K6’s expression, reduce the adhesion of pathogens to KC, against tumor necrosis factor-related antigen-inducing ligand (TRAIL) induced apoptosis of KC [2]. KC UVB ultraviolet light to activate the IL-10 gene promoter, resulting in increased IL-10. IL-10 is a Th2 type cytokines, have anti-inflammatory activity, in the UV-induced immunosuppression play a major role [3]. IL-10 have antagonistic effects of IFN- induced macrophage expression of MHC antigen down, inhibit antigen presentation [4]. inhibit the Langerhans cells (LC present antigen functions in the body block the induction period and effect of the delayed type hypersensitivity and allergic reactions effects of exposure. KC by IL-12 secretion is induced by Th1-specific immune respo