Medical calcium sulfate in the rabbit lumbar fusion model in the ability of adult bone.docVIP

 PAGE \* MERGEFORMAT 25 Medical calcium sulfate in the rabbit lumbar fusion model in the ability of adult bone Author: Zhang Jian, Bone Joint Surg Am, LIU Hai-ying, Wang Hui-min, ZHANG Sen Abstract [Objective] To be compared with autologous iliac bone, the evaluation of medical application of calcium sulfate alone osteogenic capacity, and to explore its possible mechanism of bone. [Methods] To establish a rabbit posterolateral lumbar fusion model to itself as a contrast, bilateral intertransverse bone graft and calcium sulfate particles implanted in the left side, right autogenous iliac bone implants. 3,6,12 weeks after the operation line of X ray, CT and histological examination. [Results] after 3 weeks, are still visible residual calcium sulfate particles, autologous bone completely degraded; bone can be seen within the region a large number of osteoclasts, and vascular fibrous tissue ingrowth. After 6 weeks, calcium sulfate completely degraded, imaging examination there is no significant difference between the two, showed partial bone mineral density increased, new bone forming; histology bone graft on both sides of the area are a large number of hyaline cartilage formation, autologous iliac bone graft can be seen scattered in the area of trabecular bone structure. After 12 weeks, histological and imaging on the two there is no difference between both sides of the formation of vertebral bone tissue and bone tissue in rabbits the same structure. [Conclusion] Medical calcium sulfate as a bone graft substitute materials, in addition to good bone conduction, the calcium sulfate may also have a bone-induced, their osteogenic potential of autologous iliac bone equivalent medical calcium sulfate alone can get a good integration of effect. Keywords: calcium sulfate; bone graft material; lumbar spinal posterolateral fusion 1 Introduction Calcium sulfate (calcium sulfate, CaS) for bone defect repair materials have already reached h