Metabotropic glutamate receptor subtypes in the lumbosacral spinal cord of adult monkeys in the distribution of.doc

 PAGE \* MERGEFORMAT 15 Metabotropic glutamate receptor subtypes in the lumbosacral spinal cord of adult monkeys in the distribution of Author: Shi-Ming Zhao Lei Lang Bing Jiao Ying Zhao ZW Gao Guodong [Keywords:] spinal cord Distribution of subtypes of metabotropic glutamate receptors in lumbosacral spinal cord of adult macaques [Abstract] AIM: To explore morphological evidence for the possible roles of metabotropic glutamate receptors in the lumbosacral spinal cord in adult macaques. METHODS: The distribution patterns of metabotropic glutamate receptors (mGluRs) in the lumbosacral spinal cord were studied by employing the immunohistochemical technique . RESULTS: MGluR1α distributed throughout all the laminae of spinal cord. The immunoreactive (ir) products were located on the soma or protrudes of a few interneurons together with the neuropil in the superficial layers of the spinal dorsal horn. In the deeper layers of spinal dorsal horn, intermediate nucleus and the ventral horn, mGluR1α ir neurons were observed. The neurons in the ventral horn showed the strongest immunoreactivity. mGluR5ir products, similar with those of mGluR1α , also distributed in neuropil and the soma together with protrudes of some interneurons in the superficial layers of the spinal dorsal horn. In other areas of spinal cord, however, abundant mGluR5ir neuronal soma and protrudes were also observed. MGluR2 / 3 and mGluR7 distributed in the neuropil of the superficial layers in spinal dorsal horn. No neurons showed mGluR2 / 3/mGluR7immunoreactivity. CONCLUSION: MGluRs may play some important modulatory roles in the transmission or integration of information in the spinal local circuits of the adult mammals. [Keywords] receptors, metabotropic glutamate; spinal cord; macaca mulatta; immunohistochemistry [Abstract] Objective: To explore the metabotropic glutamate receptor subtypes in the spinal cord in the rhesus monkey may provide morphological basis for the function. Methods: Im