Microscopic polyangiitis kidney damage clinicopathologic analysis of 28 cases.doc

 PAGE \* MERGEFORMAT 8 Microscopic polyangiitis kidney damage clinicopathologic analysis of 28 cases Of: Yang Lijun, Tan Feng, Li Xueying, Mengxiang Li, Liu Tong [Abstract] Objective To investigate the microscopic vasculitis of renal lesions, pathological characteristics, treatment and prognosis, for the correct diagnosis and treatment of the disease to provide information. Methods A retrospective analysis of 28 cases diagnosed as microscopic polyangiitis and renal biopsy after clinical and pathological data of patients. Results microscopic renal vasculitis is not rare kidney disease, mostly to older men, mostly of clinical nephritis kidney disease syndrome, renal damage and most of them. P-ANCA positive specificity of the diagnosis, the majority of renal pathology showed crescentic glomerulonephritis, showing fibrinoid vascular necrosis. give positive steroid and cyclophosphamide treatment. Conclusion microscopic vasculitis can affect any organ is a systemic disease kidney complex and diverse clinical manifestations, diagnosis depends on detection of serum ANCA and renal biopsy, a diagnosis to be increased by glucocorticoids and cyclophosphamide with good effect. [Keywords:] microscopic polyangiitis; kidney; ANCA Microscopic polyangiitis (microscopic polyangitis, MPA) is a small vessel vasculitis, the disease and Wegener granulomatosis, Churg-Strauss syndrome, three belong to the same anti-neutrophil cytoplasmic antibodies (AN-CA) related systemic vasculitis. As the complexity of clinical manifestations, there is no specific performance of kidney damage, so easily missed or misdiagnosed clinically. the past 10 years, due to the popularity of clinical ANCA detection, disease diagnosis increasing year by year. This collection of Xi’an Jiaotong University Department of Nephrology, First Affiliated Hospital, confirmed by renal biopsy were analyzed retrospectively 28 cases of MPA as follows. 1 Materials and Methods 1.1 Case Selection I center in J