Methotrexate treatment of ectopic pregnancy clinical observation of mifepristone.doc

 PAGE \* MERGEFORMAT 6 Methotrexate treatment of ectopic pregnancy clinical observation of mifepristone Ectopic pregnancy is a common gynecological diseases, the incidence of this year upward trend. As the serum -HCG, B, and extra fine testing technology to improve physician-depth understanding of ectopic pregnancy, has led to most of the patients received early and accurate diagnosis. but more and more urgent need to preserve fertility in patients, conservative therapy is very important. now for women with ectopic pregnancy with methotrexate (MTX) and mifepristone drug treatment reported as follows . 1 objects and methods 1.1 The object of study in January 2001 ~ December 2003 patients in our hospital 197 cases of ectopic pregnancy, including ectopic pregnancy met the inclusion criteria 60 patients with conservative treatment. Randomly divided into control group of 30 patients, the use of methotrexate individual injection; observation group of 30 patients, the use of methotrexate injection compatibility mifepristone. 1.2 study inclusion criteria of urine or blood of all patients were identified as -HCG pregnancy, B-confirmed gestational sac was no house, annex, ectopic pregnancy mass 3.5 cm in diameter were the largest; stable vital signs were no significant intra-abdominal hemorrhage ; liver and kidney function was normal and no blood diseases, voluntary for drug treatment. 1.3 The administration method according to the control group MTX 50mg / m 2 doses of intramuscular injection, and fasting morning from the date of mifepristone 75mg, 2h after eating. 21:00 Mifepristone 75mg, 2h before and after medication is still After eating, take 3 consecutive days, the total amount of drug 450mg. Observer Group: In the first 4 days after injection of methotrexate urine routine, liver and kidney function tests abnormal oral meters without mifepristone, early oral administration of 50mg, 12h after the service 50mg, medication are fast