Mongolia drug -4 taste Decoction on chemical liver injury in rats.doc

 PAGE \* MERGEFORMAT 10 Mongolia drug -4 taste Decoction on chemical liver injury in rats [Abstract] Objective To observe the effects of Baghdad -4 soup taste of D-galactosamine (D-GlaN), thioacetamide (TAA) induced liver injury in rats. Ways to protect the liver slices as a positive control, agents with different hepatic acute liver injury model in mice, serum-related indicators were measured, with the t test method differences between groups were compared. Results in Baghdad -4 flavor soup group can be reduced by D-GlaN induced liver injury in mice The ALT and AST (P lt;0.05), significantly reduced due to TAA-induced liver injury in mice, ALT and AST (P lt;0.01). model group, histological changes were mainly for piecemeal necrosis, Liver-chip group scattered points shape and small piecemeal necrosis, in Baghdad -4 flavor soup group scattered spotty necrosis, and inflammatory cell infiltration. Conclusion to Baghdad -4 soup taste different liver injury models of the above have some preventive effect, for this study efficacy and application of drugs provides an experimental basis. [Keywords:] to Baghdad -4 flavor soup; D-GlaN; TAA; acute liver injury Abstract: ObjectiveTo observe the protective and treatment action of Digeda-4 powder for D-GlaN and liver lesion of mice induced by TAA.MethodsPositively controlled with Huganpian, the above-noted liver-toxic agents were administered to make acute liver lesion of mice to measure the relative indices of animal serum.Method of t-test was used to check the difference between the groups.ResultsDigeda-4 powder decreased the serum ALT and AST of liver lesion mice induced by D-GlaN (P lt;0.05); and obviosly lowered the the serum ALT and AST of liver lesion micen induced by TAA (P lt;0.01). The change of hepatic tissues in model groups showed the piecemeal necrosis; the hepatic tissues in positive control groups showed scattered punctiform and dimin piecemeal necrosis; the hepatic tissues in Digeda-4 powder groups