MRI perfusion and diffusion-weighted imaging in comparative study of glioma classification.doc

 PAGE \* MERGEFORMAT 17 MRI perfusion and diffusion-weighted imaging in comparative study of glioma classification Study: Zou Yan Chong Qin Tai Yang Qi Lu is [Abstract] [Objective] the same group of glioma perfusion and diffusion-weighted MRI image information, compared to the two functional imaging pathological grade of glioma diagnosis. [Method] 42 patients (low-glioma 20 cases, 22 cases of advanced glioma) patients with brain glioma perfusion MRI and diffusion-weighted imaging, measurement of tumor perfusion parameters in real terms and dispersion parameters, the difference between the t test, using receiver operating characteristic curve (ROC curve) find the threshold value is determined to calculate sensitivity and specificity. of two diagnostic methods to evaluate and rate of diagnosis? word 2 test. [Results] 20 patients with low-level glioma, 22 patients with advanced glioma. low-level glue stromal tumor rCBV, rMSD, rMTT, ADC and rADC values #8203;#8203;were 2.25 + - 1.07,1.82 + - 0.70,1.07 + - 0.08, (1.36 + - 0.14) 10-3 mm2 s-1 and 1.69 + - 0.23 . Senior glioma rCBV, rMTT, rMSD, ADC and rADC values #8203;#8203;were 4.83 + - 1.84,3.36 + - 0.88,1.04 + - 0.06, (1.10 + - 0.12) 10-3 mm2 s-1 and 1.41 + - 0.18. senior and junior glioma rCBV, rMSD, ADC and rADC values #8203;#8203;were statistically significant. to rCBV value of 3.5 as the threshold value, diagnostic sensitivity was 81.8%, specificity was 90%; rMSD as the threshold value of 2.1 value, diagnostic sensitivity was 95.5%, specificity was 80%; ADC threshold of 1.23 10-3 mm2 / s, the diagnostic sensitivity of 86.4%, specificity was 85%. By the calculation of AUC and hypothesis testing found that PWI and DWI higher diagnostic accuracy, the difference was not statistically significant. [Conclusion] The rCBV values #8203;#8203;of PWI and DWI 3.5, rMSD value of 2.1, ADC value of 1.23 10-3 mm2 s-1 as the threshold value, are conducive to the identification of glioma grade. These thresholds for