- 1、本文档共13页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
MRL-lprmurineCD4CD25regulatoryTcellsandrelatedgenes
PAGE \* MERGEFORMAT 13
MRL / lpr murine CD4 + CD25 + regulatory T cells and related genes
Of: Luxue Hong Tian Geng Yang Wei Hua Li Yi Gu
[Abstract] Objective To study the MRL / lpr systemic lupus erythematosus (SLE mice (model group, the thymus, the spleen CD4 + CD25 + regulatory T cells (Tr gene number and the changes of Tr in the pathogenesis of SLE. Methods detected by indirect immunofluorescence model group and control group the level of serum anti-nuclear antibodies and flow cytometry of thymus and spleen in the number of Tr, RT PCR detection of functional genes Tr. Results of model group of anti-nuclear antibodies were positive, while the control group were negative, thymus, spleen Tr quantitative model group and control group no significant difference, Foxp3 expression level of the thymus in the model group and control group no significant difference in the model group, the spleen was lower than the control group, CTLA 4 expression levels in model group were higher than the thymus and spleen. Conclusion Tr changes in the number of MRL / lpr mice can not afford a key role in the pathogenesis, and functional changes of Tr, in particular, the functional defects in peripheral may be the One of the reasons the incidence, as the inhibitory function of Tr really changed, still needs further testing in vitro to determine the inhibitory function.
[Keywords:] MRL / lpr mice, systemic lupus erythematosus, CD4 + CD25 + regulatory T cells, mice
[Abstract] Objective To investigate CD4 + CD25 + regulatory T cells and target genes in thymus and spleen of MRL / lpr mice. Methods Serum anti nuclear antibody was detected by indirect immunofluorescence. CD4 + CD25 + Tr was determined by flow cytometry and its target genes were detected by RT PCR. Results Anti nuclear antibody was positive in model group but negative in control group. There were no significant differences of CD4 + CD25 + Tr in model and control groups. Foxp3 levels of model group was no signific
您可能关注的文档
- Mothers during delivery of psychological problems.doc
- Most private enterprises can not continue to numb anymore!.doc
- Motherwort Leonurine in the HPLC detection of.doc
- Mother of trouble - the industry leaders how to respond to market transformation.doc
- Motherwort products in the wild and cultivated products Stachydrine Comparison of the content.doc
- Mothman Kidney Capsule Determination of icariin.doc
- Motilin receptor in rat brain regions the distribution of the.doc
- Motivate your boss.doc
- Motion Strategic Brand Management.doc
- Motion sickness in rat plasma levels of calcitonin gene-related peptide changes in.doc
文档评论(0)