MRL - lpr mouse renal tissue MCPl expression and the impact of MMF on the expression and the related mechanisms.doc

 PAGE \* MERGEFORMAT 16 MRL / lpr mouse renal tissue MCPl expression and the impact of MMF on the expression and the related mechanisms [Abstract] Objective: To detect the MRL / lpr lupus mouse renal tissue monocyte chemoattractant protein 1 (MCP 1 expression and of mycophenolate mofetil (MMF their impact and the related mechanisms of MMF on the MRL / lpr lupus mice treatment. METHODS: MRL / lpr lupus mice were divided into two groups of control group and treatment group. observe the pathological changes of kidney and MCP 1, CD14 and protein kinase C (PKC expression and urinary protein, etc., anti-ds DNA antibodies level changes. Results: In control mice the glomerular basement membrane thickening, mesangial matrix increase, upregulation of renal MCP 1, CD14 + cells were significantly increased, with urine protein and anti-ds DNA antibody levels increased. small group MCP 1 expression in rat renal tissue decreased, CD14 + cells were decreased and urine protein and anti-ds DNA antibody levels decreased, and glomerular expression of MCP 1 with PKC and glomerular CD14 + cells, the urine was a linear correlation between protein levels. Conclusion : MMF on the MRL / lpr mice with spontaneous lupus nephritis has a therapeutic effect, which may be reduced by inhibiting the activation of PKC-channel MCP 1 in mice the expression of renal tissue, thereby reducing renal infiltration of mononuclear cells to reduce kidney damage. [Keywords:] monocyte chemotactic protein 1, lupus nephritis, mycophenolate mofetil, protein kinase C, mouse Recent studies have found that monocyte chemoattractant protein-1 (monocyte chemoattractant protein 1, MCP 1) is a specific monocyte chemotactic factor, can be activated monocytes and chemokine accumulation in the kidney, can also increase a Some of 2 integrin expression, to enhance the adhesion of monocytes to participate in kidney damage [1]. national study found that lupus nephritis (lupus nephritis, LN) in patients with glomerula