mTOR signaling pathway and progress of cancer research.doc

 PAGE \* MERGEFORMAT 37 mTOR signaling pathway and progress of cancer research [Abstract] mammalian target of rapamycin (mammalian target of rapamycin, mTOR) is a serine / threonine protein kinase, in cell growth, proliferation, differentiation, cell cycle regulation plays an important role in many areas. In recent years, found that mTOR signaling pathway related to the complex and wide-ranging, including abnormal regulation of many elements are closely related with the tumor. mTOR inhibitors can inhibit the abnormal signaling caused by the oncogene transformation, tumor growth and tumor angiogenesis. So far, four kinds of mTOR inhibitors are effective in clinical application, and some have entered the stage , clinical trials. Therefore, mTOR signaling pathway in-depth study of targeted therapy for cancer is important . [Keywords:] mTOR signaling pathway, rapamycin, mTOR inhibitors, cancer treatment ChinaABSTRACT: Mammalian target of rapamycin (mTOR) is a serine / threonine protein kinase that is centrally involved in the control of cell growth, proliferation, differentiation and cell cycle regulation. Recent studies have found that the mTOR pathway is complicated and the dysregulation of mTOR pathway is recognized to be associated with lots of tumors. Several inhibitors of mTOR could inhibit oncogene transformation, growth and angiogenesis of tumors. So far, four inhibitors of mTOR have been tested in clinical trials, and some have been accessed to phase or trial. Therefore, in this review, we discuss the regulators that govern mTOR pathway activity, and highlight clinical results obtained with the first generation of mTOR inhibitors to reach the oncology clinics. KEY WORDS: mTOR signaling pathway; rapamycin; mTOR inhibitor; tumor therapy Mammalian target of rapamycin (mammalian target of rapamycin, mTOR) is a serine / threonine protein kinase, from yeast to mammals, its widespread, and the evolution of very conservative. MTOR HEITMAN et al