MTHFR gene polymorphism and susceptibility to osteoporotic fracture analysis of the correlation.doc

 PAGE \* MERGEFORMAT 10 MTHFR gene polymorphism and susceptibility to osteoporotic fracture analysis of the correlation Study: Ji Bin Zhu Zhongzheng into Xiangyu Cao Chengfu [Abstract] Objective To investigate the methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism in Shanghai Han population of osteoporotic fracture the relationship between genetic susceptibility. Methods 205 patients were detected by TaqMan osteoporotic fracture patients ( fracture group) and 205 healthy people (control group) MTHFR C677T genotype distribution and differences. results in the fracture group T allele frequency was 43.7%, significantly higher (36.1%, P = 0.027), suggest T is a risk factor for fracture (OR = 1.37,95% CI = 1.04 ~ 1.82). Compared with the CC genotype, CT genotype and TT genotype increased the risk of fracture to 1.48 times (95% CI = 0.95 ~ 2.31, P = 0.083) and 2.11-fold (95% CI = 1.15 ~ 3.89, P = 0.017). the CC, CT and TT as different levels, there is allele dose-response relationship (P = 0.027) . Conclusion T increased risk of fracture, and was allele dose-response relationship, TT genotype in Chinese Han population in Shanghai osteoporotic fractures genetic susceptibility factors. [Keywords:] of osteoporotic fractures; genetic predisposition to disease; gene, methylenetetrahydrofolate reductase; gene polymorphism In recent years, genetic factors on the incidence of osteoporotic fractures of the impact of gradually taken seriously. Now have found a variety of genes associated with disease, such as vitamin D receptor, estrogen receptor, I-type collagen, etc. (1 to 3). methylenetetrahydrofolate reductase gene (MTHFR) is another important influence on the incidence of osteoporotic fracture candidate gene, its encoded protein is closely related to homocysteine metabolism, and high levels of serum of the same type cysteine acid was confirmed osteoporotic fractures in the pathogenesis (4,5). MTHFR gene in the crowd with a polymorphism in the