Multivariate repeated observations of the random coefficient model.doc

 PAGE \* MERGEFORMAT 15 Multivariate repeated observations of the random coefficient model Author: Chen Changsheng, XU Yong-Yong, Yuan Tian-Feng, Zhao Dongtao, Shang Lei, XIA Jie-lai, Pan Feng Keywords: repeated measures Multivariate random coefficients model of repeated measures data in medical research 【Abstract】 AIM: To study multivariate random coefficients model of repeated measures data in medical research. METHODS: Both diastolic and systolic blood pressures repeated measures data, collected from 120 drug abusers after taking two kinds of medicine (Drug A: Xiaoyinfuzheng, Drug B : Kelening), were analyzed by multivariate random coefficients model. The fixed effect parameters matrix x of model coefficients were estimated by using least squares estimation method, the effects between treatment groups were compared and the variancecovariance matrices of random effect were also estimated. Related analysis methods were programmed with SAS / IML code. RESULTS: Estimated parameters with fixed effect and random effect were obtained and graphs were drawn. Both diastolic and systolic blood pressures changed with time after treatment and the trends between treatment groups were different. A slow change was observed in Drug A group, while a greater curvature was found in Drug B group. Both diastolic and systolic blood pressures in Drug A group were higher than those in Drug B group. CONCLUSION: Multivariate random coefficients model can effectively analyze the dynamic change trend and random effects of multivariate repeated measures data in medical research. 【Keywords】 repeated measures; random coefficients model; multivariate statistics 【Abstract】 Objective: To study the medical data in repeated measures multivariate random coefficient model. Methods: The two drugs (A drug: consumer addiction Fuzheng capsules, B drugs: clonidine) in treatment of 120 cases of patients with diastolic and systolic blood pressure after repeated observat